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Article

Pan-Genotype Hepatitis E Virus Replication in Stem Cell-Derived Hepatocellular Systems.

Gastroenterology - 1 Feb 2018

Wu Xianfang, Dao Thi Viet Loan, Liu Peng, Takacs Constantin N, Xiang Kuanhui, Andrus Linda, Gouttenoire Jérôme, Moradpour Darius, Rice Charles M

Abstract excerpt

BACKGROUND & AIMS: The 4 genotypes of hepatitis E virus (HEV) that infect humans (genotypes 1-4) vary in geographical distribution, transmission, and pathogenesis. Little is known about the properties of HEV or its hosts that contribute to these variations. Primary isolates grow poorly in cell culture; most studies have relied on variants adapted to cancer cell lines, which likely alter virus biology. We...

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Source

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Identifiers

PMID: 29277559
DOI: 10.1053/j.gastro.2017.10.041
PMCID: PMC5811326

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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