Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Comparative study on the replication of HCV1b genome between wild-type and cell culture-adaptive mutant in regard to sensitivities against anti-HCV drugs.

Microbiology and immunology - 1 Apr 2020

Miyayama Yohei, Lee Heini, Song HoJoong, Abe-Chayama Hiromi, Miki Daiki, Imamura Michio, Chayama Kazuaki, Hijikata Makoto

Abstract excerpt

The replicon system, which mimics viral genome replication in culture cells, has been widely used to analyze the genome replication of the hepatitis C virus (HCV). However, most HCV genomes used in the system include adaptive mutations (AMs) that are vital for replication in culture cells despite the nonexistence of such mutations in the genome of wild-type (WT) HCV in patients. In order to study the genome...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antiviral Agents
Share to Cell Line

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Viral

Share to Genome, Viral

Share to Hepacivirus

Share to Mutation

Share to Replicon

Share to Virus Replication

Source

Identifiers

PMID: 31854467
DOI: 10.1111/1348-0421.12768

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Comparative study on the replication of HCV1b genome between wild-type and cell culture-adaptive mutant in regard to sensitivities against anti-HCV drugs.PMID 31854467Read ↗

Robust and persistent replication of the genotype 6a hepatitis C virus replicon in cell culture.Semantic proximity Read ↗

Development of robust genotype 1a hepatitis C replicons harboring adaptive mutations for facilitating the antiviral drug discovery and study of virus replication.Semantic proximity Read ↗

[Replication of hepatitis C virus genome].Semantic proximity Read ↗

HCV Replicon Systems: Workhorses of Drug Discovery and Resistance.Semantic proximity Read ↗

Subgenomic replicon derived from a cell line infected with the hepatitis C virus.Semantic proximity Read ↗

A Simple but Accurate Method for Evaluating Drug-Resistance in Infectious HCVcc System.Semantic proximity Read ↗

SEC14L2 enables pan-genotype HCV replication in cell culture.Semantic proximity Read ↗

On the history of hepatitis C virus cell culture systems.Semantic proximity Read ↗

Establishment of infectious genotype 4 cell culture-derived hepatitis C virus.Semantic proximity Read ↗

[Establishment of cell lines expressing HCV replicon and its applications].Semantic proximity Read ↗

Enhancement of the Replication of Hepatitis C Virus Replicons of Genotypes 1 to 4 by Manipulation of CpG and UpA Dinucleotide Frequencies and Use of Cell Lines Expressing SECL14L2 for Antiviral Resistance Testing.Semantic proximity Read ↗

Cell culture-adaptive NS3 mutations required for the robust replication of genome-length hepatitis C virus RNA.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.