Article
Search for new loci and low-frequency variants influencing glioma risk by exome-array analysis.
European journal of human genetics : EJHG - 1 May 2016
Kinnersley Ben, Kamatani Yoichiro, Labussière Marianne, Wang Yufei, Galan Pilar, Mokhtari Karima, Delattre Jean-Yves, Gousias Konstantinos, Schramm Johannes, Schoemaker Minouk J, Swerdlow Anthony, Fleming Sarah J, Herms Stefan, Heilmann Stefanie, Nöthen Markus M, Simon Matthias, Sanson Marc, Lathrop Mark, Houlston Richard S
Abstract excerpt
To identify protein-altering variants (PAVs) for glioma, we analysed Illumina HumanExome BeadChip exome-array data on 1882 glioma cases and 8079 controls from three independent European populations. In addition to single-variant tests we incorporated information on the predicted functional consequences of PAVs and analysed sets of genes with a higher likelihood of having a role in glioma on the basis of the...
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