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Article

Extracellular Matrix Stiffness Regulates Osteogenic Differentiation through MAPK Activation.

PloS one - 1 Jan 2015

Hwang Jun-Ha, Byun Mi Ran, Kim A Rum, Kim Kyung Min, Cho Hang Jun, Lee Yo Han, Kim Juwon, Jeong Mi Gyeong, Hwang Eun Sook, Hong Jeong-Ho

Abstract excerpt

Mesenchymal stem cell (MSC) differentiation is regulated by the extracellular matrix (ECM) through activation of intracellular signaling mediators. The stiffness of the ECM was shown to be an important regulatory factor for MSC differentiation, and transcriptional coactivator with PDZ-binding motif (TAZ) was identified as an effector protein for MSC differentiation. However, the detailed underlying mechanism...

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Identifiers

PMID: 26262877
DOI: 10.1371/journal.pone.0135519
PMCID: PMC4532446

Genes

MSC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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