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Article

YAP-mediated mechanotransduction tunes the macrophage inflammatory response

4 Dec 2020

Abstract excerpt

Macrophages are innate immune cells that adhere to the extracellular matrix within tissues. However, how matrix properties regulate their function remains poorly understood. Here, we report that the adhesive microenvironment tunes the macrophage inflammatory response through the transcriptional coactivator YAP. We find that adhesion to soft hydrogels reduces inflammation when compared to adhesion on stiff...

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PMID: 33277245
DOI: 10.1126/sciadv.abb8471

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