Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

NKX6.1 functions as a metastatic suppressor through epigenetic regulation of the epithelial–mesenchymal transition

10 Aug 2015

Abstract excerpt

The transcription factor NKX6.1 (NK6 homeobox 1) is important in the development of pancreatic β-cells and neurons. Although recent publications show that NKX6.1 is hypermethylated and downregulated during tumorigenesis, the function of NKX6.1 in carcinogenesis remains elusive. Here, we address the metastasis suppressor function of human NKX6.1 using cell, animal and clinical analyses. Our data show that NKX6.1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to Pancreatic and Hepatic Oncology Research
Share to Pancreatic function and diabetes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26257059
DOI: 10.1038/onc.2015.289

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

NKX6.1 functions as a metastatic suppressor through epigenetic regulation of the epithelial–mesenchymal transitionPMID 26257059Read ↗

NKX2-1-AS1 negatively regulates CD274/PD-L1, cell-cell interaction genes, and limits human lung carcinoma cell migrationSemantic proximity Read ↗

NKX6.3 Is a Transcription Factor for Wnt/β-catenin and Rho-GTPase Signaling-Related Genes to Suppress Gastric Cancer ProgressionSemantic proximity Read ↗

The Drosophila Nkx6 homeodomain protein has both activation and repression domains and can activate target gene expression.Semantic proximity Read ↗

Inactivation of NKX6.3 in the stomach leads to abnormal expression of CDX2 and SOX2 required for gastric-to-intestinal transdifferentiation.Semantic proximity Read ↗

ZEB1 in Pancreatic CancerSemantic proximity Read ↗

NKX6.3 controls gastric differentiation and tumorigenesis.Semantic proximity Read ↗

Genome-Wide Analyses of Nkx2-1 Binding to Transcriptional Target Genes Uncover Novel Regulatory Patterns Conserved in Lung Development and TumorsSemantic proximity Read ↗

Engrailed‐1 Promotes Pancreatic Cancer MetastasisSemantic proximity Read ↗

Expression profiling identifies the cytoskeletal organizer ezrin and the developmental homeoprotein Six-1 as key metastatic regulators.Semantic proximity Read ↗

EGFR feedback-inhibition by Ran-binding protein 6 is disrupted in cancerSemantic proximity Read ↗

Regulation of ZEB1 Function and Molecular Associations in Tumor Progression and MetastasisSemantic proximity Read ↗

Downregulation of nc886 contributes to prostate cancer cell invasion and TGFβ1-induced EMTSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.