Article
Inactivation of NKX6.3 in the stomach leads to abnormal expression of CDX2 and SOX2 required for gastric-to-intestinal transdifferentiation.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Feb 2016
Yoon Jung H, Choi Sung S, Kim Olga, Choi Won S, Park Yong K, Nam Suk W, Lee Jung Y, Park Won S
Abstract excerpt
Intestinal metaplasia in gastric mucosa is considered a preneoplastic lesion that progresses to gastric cancer. However, the molecular networks underlying this lesion formation are largely unknown. NKX6.3 is known to be an important regulator in gastric mucosal epithelial differentiation. In this study, we characterized the effects of NKX6.3 that may contribute to gastric intestinal metaplasia. NKX6.3 expression...
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