Article
The Drosophila Nkx6 homeodomain protein has both activation and repression domains and can activate target gene expression.
Brain research - 17 Apr 2009
Syu Li-Jyun, Uhler Jay, Zhang Huanqing, Mellerick Dervla M
Abstract excerpt
Consistent with the common role of Nkx6 family members in specifying motor neuron identity, we show that over-expression of Drosophila Nkx6 results in an increase in the number of Fasiclin II expressing motor neurons in the intersegmental nerve B branch. Our dissection of the regulatory domains of Nkx6 using chimeric cell culture assays revealed the presence of two repression domains and a single activation...
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