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EGFR feedback-inhibition by Ran-binding protein 6 is disrupted in cancer

5 Dec 2017

Abstract excerpt

Transport of macromolecules through the nuclear pore by importins and exportins plays a critical role in the spatial regulation of protein activity. How cancer cells co-opt this process to promote tumorigenesis remains unclear. The epidermal growth factor receptor (EGFR) plays a critical role in normal development and in human cancer. Here we describe a mechanism of EGFR regulation through the importin β family...

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PMID: 29229958
DOI: 10.1038/s41467-017-02185-w

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