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Article

Engrailed‐1 Promotes Pancreatic Cancer Metastasis

18 Dec 2023

Abstract excerpt

Engrailed-1 (EN1) is a critical homeodomain transcription factor (TF) required for neuronal survival, and EN1 expression has been shown to promote aggressive forms of triple negative breast cancer. Here, it is reported that EN1 is aberrantly expressed in a subset of pancreatic ductal adenocarcinoma (PDA) patients with poor outcomes. EN1 predominantly repressed its target genes through direct binding to gene...

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PMID: 38110836
DOI: 10.1002/advs.202308537

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