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Article

Downregulation of nc886 contributes to prostate cancer cell invasion and TGFβ1-induced EMT

9 Feb 2021

Abstract excerpt

Epithelial-to-mesenchymal transition (EMT) activation is important in cancer progression and metastasis. Evidence indicates that nc886 is a representative Pol III gene that processes microRNA products via Dicer and further downregulates its target gene transforming growth factor- β1 (TGF-β1), which is the most prominent inducer of EMT in prostate cancer (PC). Consistent with the previous literature, we found that...

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PMID: 35685460
DOI: 10.1016/j.gendis.2020.12.010

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