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Article

[Genetic and epigenetic abnormalities in myeloproliferative neoplasms].

[Rinsho ketsueki] The Japanese journal of clinical hematology - 1 Jun 2015

Kameda Takuro, Shide Kotaro, Shimoda Kazuya

Abstract excerpt

Mutations in JAK2, MPL and CALR are regarded as driver mutations, and are mutually exclusively detected in more than 90% of myeloproliferative neoplasms (MPNs). In addition, mutations in epigenetic regulator genes such as TET2 or DNMT3A are detected in MPNs. Although the roles of mutations in epigenetic regulator genes were clarified in normal hematopoiesis, their roles have remained unclear in malignant...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26256870
DOI: 10.11406/rinketsu.56.614

Genes

JAK2
TET2
CALR
MPL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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