Article
Disordered epigenetic regulation in the pathophysiology of myeloproliferative neoplasms.
Current hematologic malignancy reports - 1 Mar 2012
Zhang Su-Jiang, Abdel-Wahab Omar
Abstract excerpt
The discovery of mutations activating JAK-STAT signaling in the majority of patients with myeloproliferative neoplasms (MPNs) led to identification of tyrosine kinase activation as the common predominant mechanism driving MPN pathogenesis. Nevertheless, the existence of additional genetic events that modify the MPN phenotype, predate JAK2 mutations, or contribute to leukemic transformation of MPNs was suspected....
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