[Recent advances in molecular pathogenesis of myeloproliferative neoplasms].

Abstract excerpt

Myeloproliferative neoplasms (MPNs) are characterized by activation of the JAK-STAT pathway due to driver mutations including JAK2V617F and MPLW515K/L, as well as to mutations in CALR. Driver mutations phosphorylate multiple STAT proteins that lead to proliferations, differentiations and cytokine secretions of various hematopoietic cells. However, hematopoietic cells carrying JAK2V617F, which causes excessive...

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• Bone Marrow Neoplasms
• Epigenesis, Genetic
• CALR gene
• JAK2 gene
• Leukemia
• Mutation