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Article

Genetic basis and molecular pathophysiology of classical myeloproliferative neoplasms.

Blood - 9 Feb 2017

Vainchenker William, Kralovics Robert

Abstract excerpt

The genetic landscape of classical myeloproliferative neoplasm (MPN) is in large part elucidated. The MPN-restricted driver mutations, including those in JAK2, calreticulin (CALR), and myeloproliferative leukemia virus (MPL), abnormally activate the cytokine receptor/JAK2 pathway and their downstream effectors, more particularly the STATs. The most frequent mutation, JAK2V617F, activates the 3 main myeloid...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28028029
DOI: 10.1182/blood-2016-10-695940

Genes

MPL
CALR
JAK2
ASXL1
TET2

Provenance

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