Article
Genetic and epigenetic complexity in myeloproliferative neoplasms.
Hematology. American Society of Hematology. Education Program - 1 Jan 2011
Cross Nicholas C P
Abstract excerpt
The past 7 years have witnessed remarkable progress in our understanding of the genetics of BCR-ABL-negative myeloproliferative neoplasms (MPNs) and has revealed layers of unexpected complexity. Deregulation of JAK2 signaling has emerged as a central feature, but despite having biological activities that recapitulate the cardinal features MPNs in model systems, JAK2 mutations are often secondary events. Several...
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