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Article

Common single nucleotide polymorphisms at the NPC1L1 gene locus significantly predict cardiovascular risk in coronary patients.

Atherosclerosis - 1 Sept 2015

Muendlein Axel, Leiherer Andreas, Saely Christoph H, Rein Philipp, Zanolin Daniela, Kinz Elena, Brandtner Eva-Maria, Fraunberger Peter, Drexel Heinz

Abstract excerpt

BACKGROUND: Niemann-Pick C1-like 1 (NPC1L1) is involved in dietary cholesterol absorption and is the direct molecular target of the LDL-lowering drug ezetimibe. Recently, genetic variants in NPC1L1 have been associated with the incidence of cardiovascular events, but it remains unclear if the impact of NPC1L1 on cardiovascular risk is dependent on its role in cholesterol absorption. Furthermore, no direct...

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PMID: 26253792
DOI: 10.1016/j.atherosclerosis.2015.07.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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