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Article

Gene polymorphism and frequencies of the NPC1L1 gene (rs2072183, rs217434 and rs217428) in Japanese patients with dyslipidemia.

Journal of clinical pharmacy and therapeutics - 1 Oct 2014

Kashiwabara Y, Kobayashi Y, Koba S, Kohyama N, Ohbayashi M, Murayama J-I, Hirano T, Kobayashi Y, Yamamoto T

Abstract excerpt

WHAT IS KNOWN AND OBJECTIVE: Niemann-Pick C1-Like 1 (NPC1L1) plays a pivotal role in intestinal cholesterol absorption. Ezetimibe is known as an inhibitor for NPC1L1 and decreases concentration of low-density lipoprotein cholesterol (LDL-C) in blood. Responses of the decrease of serum LDL-C levels to ezetimibe have been reported to be different among NPC1L1 variants. However, there are still limited data...

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Identifiers

PMID: 24861377
DOI: 10.1111/jcpt.12176

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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