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Article

Interaction of functional NPC1 gene polymorphism with smoking on coronary heart disease.

BMC medical genetics - 18 Oct 2010

Ma Weiwei, Xu Jing, Wang Qianqian, Xin Ying, Zhang Lin, Zheng Xinxin, Wang Hu, Sun Kai, Hui Rutai, Huang Xiaohong

Abstract excerpt

BACKGROUND: The protein of Niemann-pick type C1 gene (NPC1) is known to facilitate the egress of cholesterol and other lipids from late endosomes and lysosomes to other cellular compartments. This study aims to investigate whether the genetic variation in NPC1 is associated with risk of coronary heart disease (CHD) and to detect whether NPC1 might interact with smoking on the risk of CHD. METHODS: We performed a...

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Identifiers

PMID: 20955564
DOI: 10.1186/1471-2350-11-149
PMCID: PMC2966454

Genes

NPC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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