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Article

Genetic variation in the cholesterol transporter NPC1L1, ischaemic vascular disease, and gallstone disease.

European heart journal - 1 Jul 2015

Lauridsen Bo Kobberø, Stender Stefan, Frikke-Schmidt Ruth, Nordestgaard Børge G, Tybjærg-Hansen Anne

Abstract excerpt

AIMS: Ezetimibe reduces plasma levels of low-density lipoprotein (LDL) cholesterol by inhibiting Niemann-Pick C1-Like protein 1 (NPC1L1), the transporter responsible for cholesterol uptake from the intestine into enterocytes and from the bile into hepatocytes. We tested the hypothesis that genetic variation in NPC1L1, mimicking the effect of ezetimibe, was associated with reduced risk of ischaemic vascular...

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Share to ATP Binding Cassette Transporter, Subfamily G, Member 8

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25841872
DOI: 10.1093/eurheartj/ehv108

Genes

IVD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genetic variation in the cholesterol transporter NPC1L1, ischaemic vascular disease, and gallstone disease.PMID 25841872Read ↗

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