Article
Association of NPC1L1 and HMGCR Gene Polymorphisms with Major Adverse Cardiac and Cerebrovascular Events in Patients with Three-Vessel Disease.
Human gene therapy - 1 Jun 2021
Zhao Xueyan, Li Jiawen, Tang Xiaofang, Liu Ru, Xu Jingjing, Xu Lianjun, Jiang Lin, Huang Keyong, Tian Jian, Feng Xinxing, Wu Yajie, Zhang Yin, Wang Dong, Sun Kai, Xu Bo, Zhao Wei, Hui Rutai, Gao Runlin, Song Lei, Yuan Jinqing
Abstract excerpt
Three-vessel disease (TVD) is a severe coronary heart disease (CHD) with poor prognosis. Niemann-Pick C1-like 1 (NPC1L1) is a transporter protein for exogenous cholesterol absorption, and 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) is a rate-limiting enzyme for cholesterol synthesis. We aimed to investigate the association between NPC1L1 and HMGCR gene polymorphisms and major adverse cardiac and...
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