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Etoposide: Discovery and Medicinal Chemistry

1 Sept 2004

Abstract excerpt

Etoposide is an antitumor agent currently in clinical use for the treatment of small cell lung cancer, testicular cancer and lymphomas. Since the introduction of etoposide in 1971, its mechanism of action and potent antineoplastic activity has served as the impetus for intensive research activities in chemistry and biology. This drug acts by stabilizing a normally transient DNA-topoisomerase II complex, thus...

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PMID: 15379707
DOI: 10.2174/0929867043364531

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