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RETRA exerts anticancer activity in Ewing's sarcoma cells independent of their TP53 status.

European journal of cancer (Oxford, England : 1990) - 1 May 2015

Sonnemann Jürgen, Grauel Désirée, Blümel Lisa, Hentschel Julia, Marx Christian, Blumrich Annelie, Focke Katharina, Becker Sabine, Wittig Susan, Schinkel Sandra, Krämer Oliver H, Beck James F

Abstract excerpt

Mutant p53 can exert oncogenic activity by inhibitory interaction with p73. The small-molecule RETRA has been described to disrupt this interaction and to suppress carcinoma cells (Kravchenko et al., 2008). RETRA's anticancer activity was restricted to tumour cells bearing mutant p53; it was not active in p53 negative and in p53 wild-type cells. Here, we explored the responsiveness of Ewing's sarcoma (ES) cells...

Topics

Antineoplastic Agents
Bone Neoplasms
Catechols
Cell Cycle Checkpoints
Cell Proliferation
HCT116 Cells
Humans
Mutation
Sarcoma, Ewing
Thiazoles

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tumor Cells, Cultured

Tumor Suppressor Protein p53

Source

Identifiers

PMID: 25801700
DOI: 10.1016/j.ejca.2015.02.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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