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Article

Metallothionein Is a Potential Negative Regulator of Apoptosis

15 Apr 2003

Abstract excerpt

Apoptotic resistance can either be desirable or undesirable, depending on the conditions. In cancer chemotherapy, it is critical that tumor cells are selectively and effectively killed while leaving normal cells undamaged. Since acquisition of apoptotic resistance appears to be a common occurrence during malignant transformation, elucidating the mechanisms underlying apoptotic resistance is an area of intense...

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PMID: 12700406
DOI: 10.1093/toxsci/kfg095

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