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Article

Role of p53 in cisplatin-induced tubular cell apoptosis: dependence on p53 transcriptional activity.

American journal of physiology. Renal physiology - 1 Dec 2004

Jiang Man, Yi Xiaolan, Hsu Stephen, Wang Cong-Yi, Dong Zheng

Abstract excerpt

Tubular damage by cisplatin leads to acute renal failure, which limits its use in cancer therapy. In tubular cells, a primary target for cisplatin is presumably the genomic DNA. However, the pathway relaying the signals of DNA damage to tubular cell death is unclear. In response to DNA damage, th...

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Identifiers

PMID: 15315938
DOI: 10.1152/ajprenal.00262.2004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15315938-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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