Concise Review: The Magic Act of Generating Induced Pluripotent Stem Cells: Many Rabbits in the Hat

Abstract excerpt

Since the seminal discovery by Yamanaka et al. demonstrating that four transcription factors were capable of inducing nuclear reprogramming to a pluripotent state, a plethora of publications have followed aimed at improving the efficiency, simplicity, and safety of the original methodology that was based on the use of integrating retroviruses. A better understanding of the basic mechanisms behind reprogramming as...

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