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Article

A molecular roadmap for induced multi-lineage trans-differentiation of fibroblasts by chemical combinations.

Cell research - 1 Mar 2017

Han Xiaoping, Yu Hao, Huang Daosheng, Xu Yang, Saadatpour Assieh, Li Xia, Wang Lengmei, Yu Jie, Pinello Luca, Lai Shujing, Jiang Mengmeng, Tian Xueying, Zhang Fen, Cen Yanhong, Fujiwara Yuko, Zhu Wei, Zhou Bin, Zhou Tianhua, Ouyang Hongwei, Wang Jianan, Yuan Guo-Cheng, Duan Shumin, Orkin Stuart H, Guo Guoji

Abstract excerpt

Recent advances have demonstrated the power of small molecules in promoting cellular reprogramming. Yet, the full potential of such chemicals in cell fate manipulation and the underlying mechanisms require further characterization. Through functional screening assays, we find that mouse embryonic fibroblast cells can be induced to trans-differentiate into a wide range of somatic lineages simultaneously by...

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Identifiers

PMID: 28128194
DOI: 10.1038/cr.2017.17
PMCID: PMC5339836

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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