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Reprogramming of Mouse Fibroblasts to an Intermediate State of Differentiation by Chemical Induction

1 Apr 2011

Abstract excerpt

Induced pluripotent stem cells (iPSCs) generated by forced expression of four transcription factors offer promises for regenerative and therapeutic uses in human diseases. However, it is necessary to overcome the risk of tumorigenicity caused by the use of potent oncogenes and the use of randomly integrating vectors before the iPSC technology can be applied to human medicine. Stem cells and cancer cells share...

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PMID: 21473689
DOI: 10.1089/cell.2010.0067

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