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Article

Generation of clinically relevant "induced pluripotent stem" (iPS) cells.

Journal of stem cells - 1 Jan 2011

Heffernan Corey, Sumer Huseyin, Verma Paul J

Abstract excerpt

Proviral expression of early development genes Oct4 and Sox2, in concert with cMyc and Klf4 or Nanog and Lin28, can induce differentiated cells to adopt morphological and functional characteristics of pluripotency indistinguishable from embryonic stem cells. Termed induced pluripotent stem (iPS) cells, in mice the pluripotency of these cells was confirmed by altered gene/surface antigen expression, remodeling of...

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PMID: 23264997

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