Mutation spectrum and risk of colorectal cancer in African American families with Lynch syndrome.

doi:10.1053/j.gastro.2015.07.052

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Article

Mutation spectrum and risk of colorectal cancer in African American families with Lynch syndrome.

Gastroenterology - 1 Nov 2015

Guindalini Rodrigo Santa Cruz, Win Aung Ko, Gulden Cassandra, Lindor Noralane M, Newcomb Polly A, Haile Robert W, Raymond Victoria, Stoffel Elena, Hall Michael, Llor Xavier, Ukaegbu Chinedu I, Solomon Ilana, Weitzel Jeffrey, Kalady Matthew, Blanco Amie, Terdiman Jonathan, Shuttlesworth Gladis A, Lynch Patrick M, Hampel Heather, Lynch Henry T, Jenkins Mark A, Olopade Olufunmilayo I, Kupfer Sonia S

Abstract excerpt

BACKGROUND & AIMS: African Americans (AAs) have the highest incidence of and mortality resulting from colorectal cancer (CRC) in the United States. Few data are available on genetic and nongenetic risk factors for CRC among AAs. Little is known about cancer risks and mutations in mismatch repair (MMR) genes in AAs with the most common inherited CRC condition, Lynch syndrome. We aimed to characterize phenotype,...

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Identifiers

PMID: 26248088
DOI: 10.1053/j.gastro.2015.07.052
PMCID: PMC4648287

Genes

MLH1
MSH2
MSH6
PMS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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