Article
Phenotypic and genotypic heterogeneity in the Lynch syndrome: diagnostic, surveillance and management implications.
European journal of human genetics : EJHG - 1 Apr 2006
Lynch Henry T, Boland C Richard, Gong Gordon, Shaw Trudy G, Lynch Patrick M, Fodde Riccardo, Lynch Jane F, de la Chapelle Albert
Abstract excerpt
Lynch syndrome is the most common form of hereditary colorectal cancer (CRC). This review covers the cardinal features of Lynch syndrome with particular emphasis upon its diagnostic criteria, molecular genetics, natural history, genetic counseling, surveillance and management. Considerable attention has been given to the etiologic role of mismatch repair (MMR) genes as well as low penetrance alleles and modifier...
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