Article
Prevalence and Spectrum of Germline Cancer Susceptibility Gene Mutations Among Patients With Early-Onset Colorectal Cancer.
JAMA oncology - 1 Apr 2017
Pearlman Rachel, Frankel Wendy L, Swanson Benjamin, Zhao Weiqiang, Yilmaz Ahmet, Miller Kristin, Bacher Jason, Bigley Christopher, Nelsen Lori, Goodfellow Paul J, Goldberg Richard M, Paskett Electra, Shields Peter G, Freudenheim Jo L, Stanich Peter P, Lattimer Ilene, Arnold Mark, Liyanarachchi Sandya, Kalady Matthew, Heald Brandie, Greenwood Carla, Paquette Ian, Prues Marla, Draper David J, Lindeman Carolyn, Kuebler J Philip, Reynolds Kelly, Brell Joanna M, Shaper Amy A, Mahesh Sameer, Buie Nicole, Weeman Kisa, Shine Kristin, Haut Mitchell, Edwards Joan, Bastola Shyamal, Wickham Karen, Khanduja Karamjit S, Zacks Rosemary, Pritchard Colin C, Shirts Brian H, Jacobson Angela, Allen Brian, de la Chapelle Albert, Hampel Heather
Abstract excerpt
IMPORTANCE: Hereditary cancer syndromes infer high cancer risks and require intensive cancer surveillance, yet the prevalence and spectrum of these conditions among unselected patients with early-onset colorectal cancer (CRC) is largely undetermined. OBJECTIVE: To determine the frequency and spectrum of cancer susceptibility gene mutations among patients with early-onset CRC. DESIGN, SETTING, AND PARTICIPANTS:...
Topics
- Adult
- Age of Onset
- Colorectal Neoplasms
- Genetic Predisposition to Disease
- Germ-Line Mutation