Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Target gene mutational pattern in Lynch syndrome colorectal carcinomas according to tumour location and germline mutation

1 Aug 2015

Abstract excerpt

BACKGROUND: We previously reported that the target genes in sporadic mismatch repair (MMR)-deficient colorectal carcinomas (CRCs) in the distal colon differ from those occurring elsewhere in the colon. This study aimed to compare the target gene mutational pattern in microsatellite instability (MSI) CRC from Lynch syndrome patients stratified by tumour location and germline mutation, as well as with that of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Colorectal Cancer Screening and Detection
Share to Genetic factors in colorectal cancer
Share to TGF-β signaling in diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26247575
DOI: 10.1038/bjc.2015.281

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Target gene mutational pattern in Lynch syndrome colorectal carcinomas according to tumour location and germline mutationPMID 26247575Read ↗

Colorectal carcinomas with microsatellite instability display a different pattern of target gene mutations according to large bowel site of origin.Semantic proximity Read ↗

Candidate driver genes in microsatellite‐unstable colorectal cancerSemantic proximity Read ↗

Associations of defect mismatch repair genes with prognosis and heredity in sporadic colorectal cancer.Semantic proximity Read ↗

Significance of mutations in TGFBR2 and BAX in neoplastic progression and patient outcome in sporadic colorectal tumors with high-frequency microsatellite instability.Semantic proximity Read ↗

Microsatellite instability in colorectal cancerSemantic proximity Read ↗

Microsatellite instability in colorectal cancer: from molecular oncogenic mechanisms to clinical implications.Semantic proximity Read ↗

Colorectal cancers show distinct mutation spectra in members of the canonical WNT signaling pathway according to their anatomical location and type of genetic instability.Semantic proximity Read ↗

Coding microsatellite instability analysis in microsatellite unstable small intestinal adenocarcinomas identifies MARCKS as a common target of inactivation.Semantic proximity Read ↗

The Relationship Between DNA Mismatch Repair Status and Clinicopathologic Characteristics in Colon Cancer.Semantic proximity Read ↗

Clinical and molecular characterisation of hereditary and sporadic metastatic colorectal cancers harbouring microsatellite instability/DNA mismatch repair deficiency.Semantic proximity Read ↗

Screening for germline mutations of MLH1, MSH2, MSH6 and PMS2 genes in Slovenian colorectal cancer patients: implications for a population specific detection strategy of Lynch syndrome.Semantic proximity Read ↗

Mutations in TGFbeta-RII and BAXmediate tumor progression in the later stages of colorectal cancer with microsatellite instabilitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.