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Article

Significance of mutations in TGFBR2 and BAX in neoplastic progression and patient outcome in sporadic colorectal tumors with high-frequency microsatellite instability.

Cancer genetics and cytogenetics - 1 Feb 2005

Fernández-Peralta Antonia M, Nejda Nargisse, Oliart Soledad, Medina Vicente, Azcoita Mariano Moreno, González-Aguilera Juan J

Abstract excerpt

The mutator pathway implied in the development of colorectal cancer is characterized by microsatellite instability (MSI), which is determined by alterations of mismatch repair (MMR) genes. Defects in MMR genes affect repetitive DNA tracts interspersed mostly between coding sequences, and therefore it cannot be expected that they play a role during tumor progression. Genes containing repetitive sequences within...

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Source

Identifiers

PMID: 15676142
DOI: 10.1016/j.cancergencyto.2004.05.008

Genes

TGFBR2
BAX

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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