Article
Clinical and molecular characterisation of hereditary and sporadic metastatic colorectal cancers harbouring microsatellite instability/DNA mismatch repair deficiency.
European journal of cancer (Oxford, England : 1990) - 1 Nov 2017
Cohen R, Buhard O, Cervera P, Hain E, Dumont S, Bardier A, Bachet J-B, Gornet J-M, Lopez-Trabada D, Dumont S, Kaci R, Bertheau P, Renaud F, Bibeau F, Parc Y, Vernerey D, Duval A, Svrcek M, André Thierry
Abstract excerpt
BACKGROUND: Patients treated with chemotherapy for microsatellite unstable (MSI) and/or mismatch repair deficient (dMMR) cancer metastatic colorectal cancer (mCRC) exhibit poor prognosis. We aimed to evaluate the relevance of distinguishing sporadic from Lynch syndrome (LS)-like mCRCs. PATIENTS AND METHODS: MSI/dMMR mCRC patients were retrospectively identified in six French hospitals. Tumour samples were...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.