Article
Colorectal carcinomas with microsatellite instability display a different pattern of target gene mutations according to large bowel site of origin.
BMC cancer - 27 Oct 2010
Pinheiro Manuela, Ahlquist Terje, Danielsen Stine A, Lind Guro E, Veiga Isabel, Pinto Carla, Costa Vera, Afonso Luís, Sousa Olga, Fragoso Maria, Santos Lúcio, Henrique Rui, Lopes Paula, Lopes Carlos, Lothe Ragnhild A, Teixeira Manuel R
Abstract excerpt
BACKGROUND: Only a few studies have addressed the molecular pathways specifically involved in carcinogenesis of the distal colon and rectum. We aimed to identify potential differences among genetic alterations in distal colon and rectal carcinomas as compared to cancers arising elsewhere in the l...
Topics
- Adaptor Proteins, Signal Transducing
- Base Pair Mismatch
- Cell Line, Tumor
- Colon, Sigmoid
- Colonic Neoplasms
- Colorectal Neoplasms
- DNA Repair
- Exons
- Germ-Line Mutation
- Humans