Toxoplasma gondii GRA60 is an effector protein that modulates host cell autonomous immunity and contributes to virulence.

doi:10.1111/cmi.13278

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Toxoplasma gondii GRA60 is an effector protein that modulates host cell autonomous immunity and contributes to virulence.

Cellular microbiology - 1 Feb 2021

Nyonda Mary Akinyi, Hammoudi Pierre-Mehdi, Ye Shu, Maire Jessica, Marq Jean-Baptiste, Yamamoto Masahiro, Soldati-Favre Dominique

Abstract excerpt

Toxoplasma gondii infects virtually any nucleated cell and resides inside a non-phagocytic vacuole surrounded by a parasitophorous vacuolar membrane (PVM). Pivotal to the restriction of T. gondii dissemination upon infection in murine cells is the recruitment of immunity regulated GTPases (IRGs) and guanylate binding proteins (GBPs) to the PVM that leads to pathogen elimination. The virulent T. gondii type I RH...

Topics

Animals
Antigens, Protozoan
DNA, Protozoan
Fibroblasts
Foreskin
GTP Phosphohydrolases
Gene Knockout Techniques
Host-Parasite Interactions
Humans
Immunity
Interferon-gamma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Mice

Mice, Inbred C57BL

Mutation

Protein Serine-Threonine Kinases

Protozoan Proteins

Toxoplasma

Source

Open in PubMed

Identifiers

PMID: 33040458
DOI: 10.1111/cmi.13278

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