Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Threat-related amygdala functional connectivity is associated with 5-HTTLPR genotype and neuroticism.

Social cognitive and affective neuroscience - 1 Jan 2016

Madsen Martin Korsbak, Mc Mahon Brenda, Andersen Sofie Bech, Siebner Hartwig Roman, Knudsen Gitte Moos, Fisher Patrick MacDonald

Abstract excerpt

Communication between the amygdala and other brain regions critically regulates sensitivity to threat, which has been associated with risk for mood and affective disorders. The extent to which these neural pathways are genetically determined or correlate with risk-related personality measures is not fully understood. Using functional magnetic resonance imaging, we evaluated independent and interactive effects of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amygdala
Share to Anxiety Disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Arousal

Share to Emotions

Share to Neural Pathways

Share to Neuroticism

Share to Prefrontal Cortex

Share to Serotonin Plasma Membrane Transport Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 26245837
DOI: 10.1093/scan/nsv098
PMCID: PMC4692322

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Threat-related amygdala functional connectivity is associated with 5-HTTLPR genotype and neuroticism.PMID 26245837Read ↗

5-HTTLPR/rs25531 polymorphism and neuroticism are linked by resting state functional connectivity of amygdala and fusiform gyrus.Semantic proximity Read ↗

Genetic variation in the serotonin transporter modulates neural system-wide response to fearful faces.Semantic proximity Read ↗

Aversive stimuli lead to differential amygdala activation and connectivity patterns depending on catechol-O-methyltransferase Val158Met genotype.Semantic proximity Read ↗

The 5-HTTLPR Polymorphism Affects Network-Based Functional Connectivity in the Visual-Limbic System in Healthy Adults.Semantic proximity Read ↗

Shared and Distinct Brain Regions in Anxiety, Depression, and Neuroticism: A Multi-Phenotypic Approach Using Data from the UK BiobankSemantic proximity Read ↗

5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression.Semantic proximity Read ↗

Serotonin transporter gene alters insula activity to threat in social anxiety disorder.Semantic proximity Read ↗

5-HTT genotype effect on prefrontal-amygdala coupling differs between major depression and controls.Semantic proximity Read ↗

Interaction of catechol O-methyltransferase and serotonin transporter genes modulates effective connectivity in a facial emotion-processing circuitry.Semantic proximity Read ↗

Individual differences in amygdala-medial prefrontal anatomy link negative affect, impaired social functioning, and polygenic depression risk.Semantic proximity Read ↗

Functional neuroimaging of genetic variation in serotonergic neurotransmission.Semantic proximity Read ↗

The long rather than the short allele of 5-HTTLPR predisposes Han Chinese to anxiety and reduced connectivity between prefrontal cortex and amygdala.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.