Article
5-HTTLPR/rs25531 polymorphism and neuroticism are linked by resting state functional connectivity of amygdala and fusiform gyrus.
Brain structure & function - 1 Jul 2015
Kruschwitz J D, Walter M, Varikuti D, Jensen J, Plichta M M, Haddad L, Grimm O, Mohnke S, Pöhland L, Schott B, Wold A, Mühleisen T W, Heinz A, Erk S, Romanczuk-Seiferth N, Witt S H, Nöthen M M, Rietschel M, Meyer-Lindenberg A, Walter H
Abstract excerpt
The s/s-genotype of the 5-HTTLPR polymorphism and the personality trait of neuroticism have both been associated with experiences of negative affect, anxiety and mood disorders, as well as an emotional processing bias towards negative facial emotions. On a neural level, this bias can be characterized by altered amygdala and fusiform gyrus (FFG) activity during perception of negative facial expressions. Using...
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