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Article

Comparative genomic and genetic analysis of glioblastoma-derived brain tumor-initiating cells and their parent tumors.

Neuro-oncology - 1 Mar 2016

Davis Brad, Shen Yaoqing, Poon Candice C, Luchman H Artee, Stechishin Owen D, Pontifex Carly S, Wu Wei, Kelly John J, Blough Michael D

Abstract excerpt

BACKGROUND: Glioblastoma (GBM) is a fatal cancer that has eluded major therapeutic advances. Failure to make progress may reflect the absence of a human GBM model that could be used to test compounds for anti-GBM activity. In this respect, the development of brain tumor-initiating cell (BTIC) cultures is a step forward because BTICs appear to capture the molecular diversity of GBM better than traditional glioma...

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Identifiers

PMID: 26245525
DOI: 10.1093/neuonc/nov143
PMCID: PMC4767234

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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