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Article

Association of ABCB1 and FLT3 Polymorphisms with Toxicities and Survival in Asian Patients Receiving Sunitinib for Renal Cell Carcinoma.

PloS one - 1 Jan 2015

Chu Ying-Hsia, Li Huihua, Tan Hui Shan, Koh Valerie, Lai Johnathan, Phyo Wai Min, Choudhury Yukti, Kanesvaran Ravindran, Chau Noan Minh, Toh Chee Keong, Ng Quan Sing, Tan Puay Hoon, Chowbay Balram, Tan Min-Han

Abstract excerpt

Sunitinib is a tyrosine kinase inhibitor used as first-line treatment for metastatic renal cell carcinoma (mRCC). Asian ethnicity has been previously associated with lower clearance and greater toxicities for sunitinib treatment, relative to Caucasian ethnicity. Research focusing on identifying corresponding biomarkers of efficacy and toxicity has been hitherto conducted in Caucasian populations, and few of the...

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Share to ATP Binding Cassette Transporter, Subfamily B
Share to Carcinoma, Renal Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26244574
DOI: 10.1371/journal.pone.0134102
PMCID: PMC4526634

Genes

ABCB1
FLT3
ABCG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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