Efflux pump ABCB1 single nucleotide polymorphisms and dose reductions in patients with metastatic renal cell carcinoma treated with sunitinib.

doi:10.3109/0284186X.2014.918276

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Article

Efflux pump ABCB1 single nucleotide polymorphisms and dose reductions in patients with metastatic renal cell carcinoma treated with sunitinib.

Acta oncologica (Stockholm, Sweden) - 1 Oct 2014

Beuselinck Benoit, Lambrechts Diether, Van Brussel Thomas, Wolter Pascal, Cardinaels Nina, Joniau Steven, Lerut Evelyne, Karadimou Alexandra, Couchy Gabrielle, Sebe Philippe, Ravaud Alain, Zerbib Marc, Caty Armelle, Paridaens Robert, Schöffski Patrick, Verkarre Virginie, Berger Julien, Patard Jean-Jacques, Zucman-Rossi Jessica, Oudard Stéphane

Abstract excerpt

UNLABELLED: There is growing evidence that sunitinib plasma levels have an impact on treatment outcome in patients with metastatic renal cell carcinoma (mRCC). We studied the impact of single nucleotide polymorphisms (SNPs) in genes involved in sunitinib pharmacokinetics, and additionally, sunitinib pharmacodynamics on dose reductions of the tyrosine kinase inhibitor. METHODS: We retrospectively analyzed...

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PMID: 24874929
DOI: 10.3109/0284186X.2014.918276

Genes

ABCB1

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