Article
Effects of single nucleotide polymorphisms on treatment outcomes and toxicity in patients treated with sunitinib.
Anticancer research - 1 Oct 2013
Maeng Chi Hoon, Yi Jun Ho, Lee Jeeyun, Hong Jung Yong, Choi Moon Ki, Jung Hyun Ae, Park Joon Oh, Park Se Hoon, Park Young Suk, Kang Won Ki, Lim Ho Yeong
Abstract excerpt
BACKGROUND/AIM: We analyzed the efficacy and toxicity profile of sunitinib according to single nucleotide polymorphisms (SNPs) of vascular endothelial growth factor receptor (VEGFR) and Kinase insert domain receptor (KDR). PATIENTS AND METHODS: We examined eight known SNPs of VEGFA and five SNPs of KDR among patients with gastric or biliary tract cancer who were treated with sunitinib. We retrospectively assessed...
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