Article
Effect of the CYP3A5 and ABCB1 genotype on exposure, clinical response and manifestation of toxicities from sunitinib in Asian patients.
The pharmacogenomics journal - 1 Feb 2016
Teo Y L, Wee H L, Chue X P, Chau N M, Tan M-H, Kanesvaran R, Wee H L, Ho H K, Chan A
Abstract excerpt
The objective of this study was to determine the effect of the CYP3A5 and ATP binding cassette subfamily B member 1 (ABCB1) single-nucleotide polymorphisms on the disposition of sunitinib and SU12662, on clinical response, and on the manifestation of toxicities in Asian metastatic renal cell carcinoma patients. At week 4 of each treatment cycle, toxicities and plasma steady-state levels were assessed. Clinical...
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