Single nucleotide polymorphism associations with response and toxic effects in patients with advanced renal-cell carcinoma treated with first-line sunitinib: a multicentre, observational, prospective study.

doi:10.1016/S1470-2045(11)70266-2

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Article

Single nucleotide polymorphism associations with response and toxic effects in patients with advanced renal-cell carcinoma treated with first-line sunitinib: a multicentre, observational, prospective study.

The Lancet. Oncology - 1 Nov 2011

Garcia-Donas Jesus, Esteban Emilio, Leandro-García Luis Javier, Castellano Daniel E, González del Alba Aranzazu, Climent Miguel Angel, Arranz José Angel, Gallardo Enrique, Puente Javier, Bellmunt Joaquim, Mellado Begoña, Martínez Esther, Moreno Fernando, Font Albert, Robledo Mercedes, Rodríguez-Antona Cristina

Abstract excerpt

BACKGROUND: Sunitinib is a tyrosine kinase inhibitor with proven efficacy in renal-cell carcinoma, but some patients do not respond or need dose reductions due to toxicity. Because there are no validated molecular predictors of response or toxicity to sunitinib, we aimed to identify genetic markers predictive of outcome and toxic effects. METHODS: In our observational, prospective study we enrolled previously...

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PMID: 22015057
DOI: 10.1016/S1470-2045(11)70266-2

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ABCB1

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