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Article

Site-specific fluorescent labeling and oriented immobilization of a triple mutant of CYP3A4 via C64.

Bioconjugate chemistry - 18 Apr 2012

Ménard Amélie, Huang Yue, Karam Pierre, Cosa Gonzalo, Auclair Karine

Abstract excerpt

The generation of site-specific bioconjugates of proteins is highly desired for a number of biophysical and nanotechnological applications. To this end, many strategies have been developed that allow the specific modification of certain canonical amino acids and, more recently, noncanonical functional groups. P450 enzymes are heme-dependent monooxygenases involved in xenobiotic metabolism and in the biosynthesis...

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Identifiers

PMID: 22433037
DOI: 10.1021/bc200672s
PMCID: PMC5233439

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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