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Article

Identification of genotoxic compounds using isogenic DNA repair deficient DT40 cell lines on a quantitative high throughput screening platform.

Mutagenesis - 1 Jan 2016

Nishihara Kana, Huang Ruili, Zhao Jinghua, Shahane Sampada A, Witt Kristine L, Smith-Roe Stephanie L, Tice Raymond R, Takeda Shunichi, Xia Menghang

Abstract excerpt

DNA repair pathways play a critical role in maintaining cellular homeostasis by repairing DNA damage induced by endogenous processes and xenobiotics, including environmental chemicals. Induction of DNA damage may lead to genomic instability, disruption of cellular homeostasis and potentially tumours. Isogenic chicken DT40 B-lymphocyte cell lines deficient in DNA repair pathways can be used to identify genotoxic...

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Identifiers

PMID: 26243743
DOI: 10.1093/mutage/gev055
PMCID: PMC4723671

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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