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Article

Cell-based assays for identification of novel double-strand break-inducing agents.

Journal of the National Cancer Institute - 16 Jan 2002

Dunstan Heather M, Ludlow Catherine, Goehle Sondra, Cronk Michelle, Szankasi Philippe, Evans David R H, Simon Julian A, Lamb John R

Abstract excerpt

BACKGROUND: We are developing cell-based assays to identify anticancer agents that are selectively toxic to cells with defined mutations. As a test, we used a three-stage strategy to screen compounds from the National Cancer Institute's repository for agents that are selectively toxic to double-strand break repair-deficient yeast cells. METHODS: Compounds identified in the screen were further analyzed by use of...

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PMID: 11792746
DOI: 10.1093/jnci/94.2.88

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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