Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Combinatorial Measurement of CDKN1A/p21 and KIF20A Expression for Discrimination of DNA Damage-Induced Clastogenicity

26 Sept 2014

Abstract excerpt

In vitro mammalian cytogenetic tests detect chromosomal aberrations and are used for testing the genotoxicity of compounds. This study aimed to identify a supportive genomic biomarker could minimize the risk of misjudgments and aid appropriate decision making in genotoxicity testing. Human lymphoblastoid TK6 cells were treated with each of six DNA damage-inducing genotoxins (clastogens) or two genotoxins that do...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to DNA Repair Mechanisms
Share to Microtubule and mitosis dynamics

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25264741
DOI: 10.3390/ijms151017256

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Combinatorial Measurement of CDKN1A/p21 and KIF20A Expression for Discrimination of DNA Damage-Induced ClastogenicityPMID 25264741Read ↗

Development of an integrated assay in human TK6 cells to permit comprehensive genotoxicity analysis in vitro.Semantic proximity Read ↗

Toxicogenomics: overview and potential applications for the study of non-covalent DNA interacting chemicals.Semantic proximity Read ↗

A new genotoxicity assay based on p53 target gene induction.Semantic proximity Read ↗

[Progress of the micronucleus test in the field of molecular cancer epidemiology].Semantic proximity Read ↗

Network responses to DNA damaging agents.Semantic proximity Read ↗

Identification of genotoxic compounds using isogenic DNA repair deficient DT40 cell lines on a quantitative high throughput screening platform.Semantic proximity Read ↗

Uracil DNA glycosylase (UNG) loss enhances DNA double strand break formation in human cancer cells exposed to pemetrexedSemantic proximity Read ↗

Consensus findings of an International Workshops on Genotoxicity Testing Workshop on using Transcriptomic biomarkers to predict genotoxicitySemantic proximity Read ↗

Dual-directional epi-genotoxicity assay for assessing chemically induced epigenetic effects utilizing the housekeeping TK geneSemantic proximity Read ↗

Genetic method for pre-classification of genotoxins into monofunctional or cross-linking agents.Semantic proximity Read ↗

Drug-induced DNA damage and tumor chemosensitivity.Semantic proximity Read ↗

Role of aneuploidy in the carcinogenic process: Part 3 of the report of the 2017 IWGT workgroup on assessing the risk of aneugens for carcinogenesis and hereditary diseases.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.