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Article

The BlueScreen-384 assay as an indicator of genotoxic hazard potential in early-stage drug discovery.

Journal of biomolecular screening - 1 Apr 2013

Simpson Kate, Bevan Nicola, Hastwell Paul, Eidam Patrick, Shah Poonam, Gogo Elke, Rees Steve, Brown Andrew

Abstract excerpt

High-throughput cell-based techniques that permit early detection of compound-induced genotoxic damage have recently become available. Methods based on induction of the GADD45a promoter are attractive because multiple intracellular mechanisms that detect genetic damage intersect at this checkpoint gene. Consequently, assays such as GreenScreen HC, which uses p53-competant human TK6 lymphoblastoid cells and a...

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PMID: 23264450
DOI: 10.1177/1087057112470858

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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